Hotline +49 6131 39-22122. Consequently, normal brain function relies on the correct regulation of single neuron properties, such as their synaptic connections, morphology, and membrane currents. Somos uma instituição de Educação que atua nas áreas de Treinamento em Desenvolvimento Profissional e Gerencial desde fevereiro de 2003. Consoulas C, Duch C, Bayline RJ, Levine RB (2000) Behavioral transformations during metamorphosis: remodeling of neural and motor systems. Kadas D, Duch C, Consoulas C. (2019) Postnatal Increases in Axonal Conduction Velocity of an Identified Drosophila Interneuron Require Fast Sodium, L-Type Calcium and Shaker Potassium Channels. Toplinks. The Ernst Florey memory lecture. report that competitive mechanisms are required to correctly partition synaptic inputs from different transmitter systems on the dendritic arbor of a Drosophila motoneuron. Neurons are the building blocks of the brain. eNeuro. : +49 (0) 6131 / 39 - 21979 Fax: +49 (0) 6131 / 39 - 23 004. Front Syst Neurosci. Ryglewski S, Kilo L, Duch C (2014) Sequential acquisition of cacophony calcium currents, sodium channels and voltage-dependent potassium currents affects spike shape and dendrite growth during postembryonic maturation of an identified Drosophila motoneuron Eur J Neurosci, 39(10):1572-85. Bayline RJ, Duch C, Levine RB (2001) Nerve-muscle interactions regulate motor terminal growth and myoblast distribution during muscle development. PLoS Biol 5(4):e66. We use the versatile genetic model system Drosophila melanogaster for our research. Duch C, Mentel T, Pflueger HJ (1999) Distribution and activation of different types of octopaminergic DUM neurons in the locust. Biozentrum 1 Hanns-Dieter-Hüsch-Weg 15, 2nd Floor, Room 02.352 55128 Mainz Tel: +49 6131/3923419 Fax: +49 6131/3925443 e-mail: cduch@uni-mainz.de. Close affiliations . Page-Name:IDN Homepage Last Update:12.October 2017 Institute of Neurobiology, Johannes Gutenberg University of Mainz, 55099 Mainz, Germany. J Comp Physiol A: 196(1):37-50. Duch, Univ.-Prof. Dr. Carsten Address: Hanns-Dieter-Hüsch-Weg 15,55128 Mainz Building: BioZentrum I (1578) Room: 02-352 Phone: +49 6131 39 23419 Pflueger HJ, Duch C, Heidel E (2004) Neuromodulatory octopaminergic neurons and their functions during insect motor behaviour. Evers JF, Schmitt S, Scholz M, Duch C (2005) New frontiers in functional neuroanatomy: precise automatic reconstruction from confocal image stacks. Neuron 93(3):632-645.e6. Pathobiochem., UM Mainz: Carsten Duch Inst. Cell Tissue Res 334:477-498. Johannes Gutenberg-Universität Mainz Jakob-Welder-Weg 9 55099 Mainz. J Neurosci 37(45):10971-10982. When analyzing the role of dendrites, the experimental challenge is to abolish them selectively in identified Drosophila wing motoneurons without affecting other properties of these specific neurons or others. The University of Mainz (full name Johannes Gutenberg University Mainz) (German: Johannes Gutenberg-Universität Mainz) is a public research university in Mainz, Rhineland Palatinate, Germany, named after the printer Johannes Gutenberg since 1946. Physiology, UM Mainz: Amparo Acker-Palmer Cell Biology, GU Frankfurt: Eva-Maria Albers Dept. Mol Neurobiol 29:303-320. J Neurosci 15:1109-1113. Brain Res Bulletin 53:571-583. E-Mail. Institute of Neurobiology, Johannes Gutenberg University of Mainz, Mainz, Germany. Meseke M, Evers JF, Duch C (2009) Postembryonic dendritic remodeling of an identified neuron is accompanied by changes in synapse distribution and dendritic input computation. Hohensee S, Bleiss W, Duch C (2008) Correlative electron and confocal microscopy assessment of synapse localization in the central nervous system of an insect. J Comput Neurosci 34(2):211-29. Group (private) – Master of Education, Uni Mainz. Additional information about this page. Dutta S, Rieche F, Eckl N, Duch C, Kretzschmar D (2015) Glial expression of Swiss-Cheese, the Drosophila orthologue of Neuropathy Target Esterase, is required for neuronal ensheathment and function. • determine the functional consequences of correct and false regulation of neuronal properties for synaptic integration, neuronal firing patterns, and behavior in the healthy and in the diseased brain. eNeuro. Duch C, Mentel T (2003) Motoneuron terminal retraction and outgrowth depend on stage-specific activity patterns during the metamorphosis of Manduca sexta. Prof. Dr. Carsten Duch. Consequently, normal brain function relies on the correct regulation of single neuron properties, such as their synaptic connections, morphology, and … Duch C, Levine RB (2002) Changes of calcium signaling during postembryonic dendritic growth in Manduca sexta. Mainz é uma cidade independente ( kreisfreie Stadt ) ou distrito urbano ( Stadtkreis ), ou seja, possui estatuto de distrito ( … Burkert P, Duch C (2006) Developmental changes of CaMKII localization, activity and function during postembryonic CNS remodeling in Manduca sexta. 1. J Insect Physiol 54(1):240-54. University Information Security and Privacy © 2020 The Arizona Board of Regents on behalf of The University of Arizona.The University of Arizona. 9.00-12.00) Tel. Therefore, even with a complete connectome in hand, understanding brain function requires an intricate analysis of the physiology and functional morphology of its component neurons. The biogenic amines octopamine (OA) and tyramine (TA) modulate insect motor behavior in an antagonistic manner. Email: cduch@uni-mainz.de Search for more papers by this author Adrenergic signaling profoundly modulates animal behavior. Hutchinson K, Vonhoff F, Duch C (2014) Dscam1 is required for normal dendrite growth and branching but not for dendritic spacing in Drosophila motoneurons. Group (open) – Master Erziehungswissenschaft, Uni Mainz. Kuehn C, Duch C (2008) Expression of two different isoforms of fasciclin II during postembryonic central nervous system remodeling in Manduca sexta. Institute of Neurobiology, Johannes Gutenberg University of Mainz, 55099 Mainz, Germany cduch@uni-mainz.de. Nove de Julho, 5229 - 5° Andar Advising by appointment only. Duch C, Levine RB (2000) Remodeling of membrane properties and dendritic architecture accompany the postembryonic conversion of a ‘slow’ into a ‘fast’ motoneuron. Disease Models & Mechanisms, Dec 3 [Epub ahead of print]. J Comp Neurol, 518:2169-2185. Mol. Raum 01-230 (Gebäude Recht und Wirtschaft I) Tel. Williams AA, White R, Sniard A, Corneveaux J, Huentelman M, Duch C (2016) MECP2 impairs neuronal structure by regulating KIBRA. Pflueger HJ, Duch C (2000) The functional role for octopaminergic neurons in insect motor behavior. Neurons are the building blocks of the brain. (2)Institute of Molecular Biology, Johannes Gutenberg University Mainz, 55099 Mainz, Germany. Biogenic amines, like norepinephrine, can act as neuromodulators to render animal behavior adaptive to changing external and internal conditions. Mar 19;12:5. doi: 10.3389/fnsys.2018.00005. J Exp Biol 202:3555-3564. Vierk R, Pflueger HJ, Duch C (2010) Postembryonic development of centrally generated flight motor patterns in the hawkmoth, Manduca sexta. Libersat F, Duch C (2002) Morphometric analysis of dendritic remodeling in an identified motoneuron during postembryonic development. awiercze@students.uni-mainz.de, anna.wierczeiko@lir-mainz.de. Homepage. Proceedings of the National Academy of … Ryglewski S, Pflueger HJ, Duch C (2007) Expanding the Neuron’s Calcium Signaling Repertoire: Intracellular Calcium Release via Voltage induced PLC and IP3R Activation. In addition to the unprecedented genetic tools available in Drosophila, the transformation from the larval to the adult stage during metamorphosis is a striking example of postembryonic nervous system plasticity and remodeling, and the functions of individually identified neurons can directly be related to stage specific behaviors. and the secretary: Renate Bertgen. Duch C, Vonhoff F, Ryglewski S (2008) Dendrite elongation and dendritic branching are affected separately by different forms of intrinsic motoneuron excitability. Please note: Due to the amount of requests reaching the “Studierendenservice” at the moment there is a delay up to one week in answering them. Group (closed) – BA Erziehungswissenschaften, Uni Mainz. (3)Institute of Developmental Biology and Neurobiology, Johannes Gutenberg University Mainz, 55099 Mainz, Germany; ryglewsk@uni-mainz.de cduch@uni-mainz.de. Mainz, Renânia-Palatinado, Alemanha: Presidente Georg Krausch Total de estudantes: 37 039 Página oficial website oficial: A Universidade Johannes Gutenberg de Mainz (em alemão: Johannes Gutenberg-Universität Mainz) é uma instituição de ensino superior localizada em Mainz, no estado da Renânia-Palatinado, Alemanha. J Comp Neurol 450:153-166. J Physiol J Physiol 590(Pt 4):809-25. J Comp Neurol 403:119-134. Meseke M, Evers JF, Duch C (2009) PTX-induced hyperexcitability affects dendritic shape and GABAergic synapse density but not synapse distribution during Manduca postembryonic motoneuron development. Development 140(3):606-16. Ryglewski S, Lance K, Levine RB, Duch C (2012) Cav2 Channels Mediate LVA and HVA Calcium Currents in Drosophila Motoneurons. Biozentrum 1 Hanns-Dieter-Hüsch-Weg 15, 2nd Floor, Room 02.356 D 55128 Mainz Mo. Background: To compare the efficacy and safety of timolol 0.5% versus brinzolamide 1.0% when added to travoprost monotherapy in patients with primary open-angle glaucoma or ocular hypertension. Die Entfernung von Graffiti kostet die Johannes Gutenberg-Universität jährlich rund 80.000 Euro. Stocker B, Bochow C, Damrau C, Mathejczyk T, Wolfenberg H, Colomb J, Weber C, Ramesh N, Duch C, Biserova NM, Sigrist S, Pflüger HJ. J Comp Physiol A: 195(3):265-77. Vonhoff F, Kühn C, Blumenstock S°, Sanyal S, Duch C (2013) A precise temporal coherency between receptor expression, neural activity, and AP-1 dependent transcription regulates dendrite development in an identified Drosophila motoneuron. Baudoux S, Duch C, Morris OT (1998) Coupling of efferent neuromodulatory neurons to rhythmical leg motor activity in the locust. - Fr. Vierk R, Pflueger HJ, Duch C (2009) Differential effects of octopamine and tyramine on the central pattern generator for Manduca flight. J Neurosci 34(5):1924-31. Perturbations cause dendrite shifts and result in defects of adaptive motor control. Mainz [1] [2] [3] ou Mogúncia [4] [5] (em alemão: Mainz, em latim: Mogontiacum, em francês: Mayence) é uma cidade da Alemanha, capital do estado federal de Renânia-Palatinado. Ryglewski S, Duch C (2012) Preparation of Drosophila Central Neurons for in situ Patch Clamping. 1990-1994 Study of Biology, Free University Berlin 1994 Diploma of Biology, Free University Berlin 1995-1998 PhD Student at the Institute of Neurobiology, Free University Berlin (2018) Structural and Molecular Properties of Insect Type II Motor Axon Terminals. Kadas D, Ryglewski S, Duch C (2015) Transient BK outward current enhances motoneurone firing rates during Drosophila larval locomotion. PNAS 116(9):3805-3810. Alles zur Johannes-Gutenberg-Universität Mainz und ihren 204 Studiengängen. PLoS One, 7(2):e31835. Kadas D, Duch C, Consoulas C. (2019) Postnatal Increases in Axonal Conduction Velocity of an Identified Drosophila Interneuron Require Fast Sodium, L-Type Calcium and Shaker Potassium Channels. Stefanie Ryglewski, Ph.D., ryglewsk@uni-mainz.de. J Neurophysiol 93:2331-2342. To understand the adaptive regulation of these properties our research objectives are: • identify the molecular mechanisms that regulate electrical and morphological properties of neurons. doi: 10.1523/ENEURO.0181-19.2019. Ryglewski S, Kadas S, Hutchinson K, Schuetzler N, Vonhoff F, Duch C (2014) Dendrites are dispensable for basic motoneuron function but essential for fine tuning of behavior. J Neurophysiol 100(5):2525-36. DEGREE COURSE: Guide to the Bachelors and Masters Degree Programs Schützler N, Girwert C, Hügli I, Mohana G, Roignant JY, Ryglewski S*, Duch C* (2019) Tyramine action on motoneuron excitability and adaptable tyramine/octopamine ratios adjust Drosophila locomotion to nutritional state. Duch C, Pflueger HJ (1999) DUM neurons in locust flight: a model system for amine mediated peripheral adjustments to a central motor program. Fax +49 6131 39-25548. Die spätstaufische Burg der Erzbischöfe und Kurfürsten von Mainz wurde um das Jahr 1245 zum Schutz des Gebiets an der Lahnmündung erbaut. Dev Biol 297(1):214-227. Duch C 2 Affiliations . Libersat F, Duch C (2004) Cellular and molecular mechanisms of the maturation of neuronal dendritic trees. However, in a computing, adapting, and learning system such as the brain, these properties must also retain functional plasticity. Duch C, Pflueger HJ (1995) Motor patterns for horizontal and upside down walking and vertical climbing in the locust. Wären Kameras an besonders betroffenen Stellen … University Information Security and Privacy © 2020 The Arizona Board of Regents on behalf of The University of Arizona.The University of Arizona. Besucheranschrift / Office: Hanns-Dieter-Hüsch-Weg 15 (Gebäude 1578, 2.Stock, 02-352) 55128 Mainz Kathryn Scheckel, Carsten Duch Correspondence cduch@uni-mainz.de In Brief Ryglewski et al. eCollection 2018. J Exp Biol 198:1963-1976. * Shared last author. J Neurophysiol 102(6):3673-88. European J Neurosci 17:1-18. Mentel T, Duch C, Müller U, Stypa H, Wegener G, Pflueger HJ (2003) Fuel selection in locust flight muscle by the activity of central modulatory neurons. Duch C, Bayline RJ, Levine RB (2000) Development of the DLM flight motor system in Manduca sexta. Cell Biology, JGU Mainz: Albrecht Clement Inst. Duch's work group at Mainz University is investigating dendritic structures and functions using the fruit fly Drosophila as a model organism. Arbeitsgruppe von der Theorie zur Forschungspraxis. Gaitanidis A, Dimitriadou A, Dowse H, Sanyal S, Duch C, Consoulas C. (2019) Longitudinal assessment of health-span and pre-death morbidity in wild type Drosophila. Includes free vocabulary trainer, verb tables and pronunciation function. Gaitanidis A, Dimitriadou A, Dowse H, Sanyal S, Duch C, Consoulas C. (2019) Longitudinal assessment of health-span and pre-death morbidity in wild type Drosophila. 2. Pflueger HJ, Duch C (2011) Dynamic neural control of insect muscle metabolism related to motor behavior. mail.uni-mainz.de links to network IP address 134.93.178.3. J Comp Physiol 195(5):473-89. Find more data about mail. J Neurophysiol 102:41-58. J Physiol 593(22):4871-88. J Comp Neurol 422:1-17. Fields L, Duch C, Pflueger HJ (2007) Reflex activation of octopaminergic unpaired median neurons in the locust. Duch C (2006) Form and function of identified insect motoneurons. J Neurophysiol 79:361-370. 55099 Mainz Germany. Die rechteckige Kernburg ist von vier Gebäudeflügeln und einer Schildmauer mit Ecktürmen umgeben. Front Syst Neurosci 11:68, Kadas D, Klein A, Krick N, Worrell JW, Ryglewski S, Duch C (2017) Dendritic and Axonal L-Type Calcium Channels Cooperate to Enhance Motoneuron Firing Output during Drosophila Larval Locomotion. www.uni-mainz.de. University Medical Center Mainz | 2,450 followers on LinkedIn. Neurobiol of Disease, in press. Eur J Neurosci, 37(6):860-75. Kühn C, Duch C (2013) Putative Excitatory and Putative Inhibitory Inputs Localize to Different Dendritic Domains in a Drosophila Flight Motoneuron. Current project. Logo der Johannes Gutenberg-Universität Mainz, Zusätzliche Informationen zu dieser Seite. Lukas Kilo, Ph.D. Student, kilo@uni-mainz.de Börner J, Duch C (2010) A standard neuroanatomy atlas for the adult Drosophila ventral nerve cord. Group leader. Herrera-Valdez MA, McKiernan EC*, Berger SD*, Ryglewski S, Duch C, Crook S (2013) Relating ion channel expression, bifurcation structure, and diverse firing patterns in a model of an identified motor neuron. Duch C, Mentel T (2004) Activity affects dendritic shape and synapse elimination during steroid induced dendritic regression in Manduca sexta. Eur J Neurosci 23:335-349. Mit Erfahrungsberichten, NC-Liste und zulassungsfreien Studiengängen. Ryglewski S, Duch C (2009) Shaker and Shal mediate transient calcium-independent potassium current in a Drosophila flight motoneuron. Each neuron must acquire a specific ‘Gestalt’ and a defined set of ion channels during development and maintain them within critical ranges throughout life. doi: 10.1523/ENEURO.0181-19.2019. To address these questions we use Drosophila melanogaster as a model system. Int Comp Biol 46:E36. Ryglewski S, Duch C, Altenhein B (2017) Tyramine Actions on Drosophila Flight Behavior Are Affected by a Glial Dehydrogenase/Reductase. Aging (Albany NY). Johannes Gutenberg University Mainz was originally founded in 1477 and today still strives to emulate the innovational spirit of its namesake. Look up the English to German translation of uni Mainz in the PONS online dictionary. Approximately 100 billion neurons in our brain form 100 trillion synapses onto 100,000 miles of dendritic cable. Here we genetically remove dendrites in Drosophila motoneurons, followed by analysis of functional outcomes. E-mail: sac@unieducar.org.br Fone: 0800.005.3005 Escritório em São Paulo - SP: Av. Schmitt S, Evers JF, Scholz M, Duch C, Obermayer K (2004) New methods for the computer assisted 3D reconstruction of neurons from confocal image stacks. Acta Biol Hung 51:343-348. Burg Lahneck. We are interested in the functional diversity of voltage gated calcium channels and its implications for normal neurophysiology ans behavior. Corresponding author C. Duch: Institute of Neurobiology, Johannes Gutenberg University of Mainz, Col.‐ Kleinmann Weg 2, 55099 Mainz, Germany. J Vis Exp 15;(68). Uni Mainz. Exkursion LL BiMA. OA generally enhances locomotor behaviors such as Drosophila larval crawling and flight, whereas TA decreases locomotor activity. ℹ️ mail.uni-mainz.de receives about 38,037 unique visitors per day, and it is ranked 25,698 in the world. Evers JF, Muench D, Duch C (2006) Developmental relocation of presynaptic terminals along distinct types of dendritic filopodia. Vonhoff F, Duch C (2010) Tiling Among Stereotyped Dendritic Branches in an Identified Drosophila Motoneuron. E-Mail: joerg.korff@uni-mainz… Cell Tissue Res 325:175-87. Arbeitsgruppe/Research team Prof. Dr. C. Duch. Vonhoff F, Williams A, Ryglewski S, Duch C (2012) Drosophila as a Model for MeCP2 Gain of Function in Neurons. Corresponding Author. With approximately 32,000 students (2018) in about 100 schools and clinics, it is among the largest universities in Germany. Synapses determine information processing between neurons, whereas electrical properties as well as structure determine information processing within neurons. J Neurosci 20:6950-6961. 11(6):1850-1873. doi: 10.18632/aging.101880. J Neurophysiol 87:1415-1425. Dev Biol 231:348-363. Accordingly, dendritic defects are consistent anatomical correlates of numerous brain diseases, but specific causality remains unproven.