Kadas D, Duch C, Consoulas C. (2019) Postnatal Increases in Axonal Conduction Velocity of an Identified Drosophila Interneuron Require Fast Sodium, L-Type Calcium and Shaker Potassium Channels. Homepage. Evers JF, Muench D, Duch C (2006) Developmental relocation of presynaptic terminals along distinct types of dendritic filopodia. Inst. Page-Name:IDN Homepage Last Update:12.October 2017 Corresponding author C. Duch: Institute of Neurobiology, Johannes Gutenberg University of Mainz, Col.‐ Kleinmann Weg 2, 55099 Mainz, Germany. Duch's work group at Mainz University is investigating dendritic structures and functions using the fruit fly Drosophila as a model organism. ⢠determine the functional consequences of correct and false regulation of neuronal properties for synaptic integration, neuronal firing patterns, and behavior in the healthy and in the diseased brain. University Medical Center Mainz | 2,450 followers on LinkedIn. Please note: Due to the amount of requests reaching the “Studierendenservice” at the moment there is a delay up to one week in answering them. 11(6):1850-1873. doi: 10.18632/aging.101880. Fields L, Duch C, Pflueger HJ (2007) Reflex activation of octopaminergic unpaired median neurons in the locust. www.uni-mainz.de. J Comput Neurosci 34(2):211-29. * Shared last author. Ryglewski S, Pflueger HJ, Duch C (2007) Expanding the Neuronâs Calcium Signaling Repertoire: Intracellular Calcium Release via Voltage induced PLC and IP3R Activation. Hotline +49 6131 39-22122. J Neurosci 15:1109-1113. Duch C (2006) Form and function of identified insect motoneurons. Dutta S, Rieche F, Eckl N, Duch C, Kretzschmar D (2015) Glial expression of Swiss-Cheese, the Drosophila orthologue of Neuropathy Target Esterase, is required for neuronal ensheathment and function. Die Entfernung von Graffiti kostet die Johannes Gutenberg-Universität jährlich rund 80.000 Euro. Johannes Gutenberg University Mainz was originally founded in 1477 and today still strives to emulate the innovational spirit of its namesake. ℹ️ mail.uni-mainz.de receives about 38,037 unique visitors per day, and it is ranked 25,698 in the world. J Neurosci 34(5):1924-31. Neurons are the building blocks of the brain. Arbeitsgruppe von der Theorie zur Forschungspraxis. Gaitanidis A, Dimitriadou A, Dowse H, Sanyal S, Duch C, Consoulas C. (2019) Longitudinal assessment of health-span and pre-death morbidity in wild type Drosophila. Unravel Resilience - Using Multi-Omics Integration to explore the Molecular Background of Stress Resilience Resilience is the ability to cope with stress or to quickly recover to pre-crisis state after being exposed to extreme stress. Pathobiochem., UM Mainz: Carsten Duch Inst. Cell Biology, JGU Mainz: Albrecht Clement Inst. - Fr. Duch C, Pflueger HJ (1995) Motor patterns for horizontal and upside down walking and vertical climbing in the locust. J Insect Physiol 54(1):240-54. Consequently, normal brain function relies on the correct regulation of single neuron properties, such as their synaptic connections, morphology, and membrane currents. Find more data about mail. Duch, Univ.-Prof. Dr. Carsten Address: Hanns-Dieter-Hüsch-Weg 15,55128 Mainz Building: BioZentrum I (1578) Room: 02-352 Phone: +49 6131 39 23419 Includes free vocabulary trainer, verb tables and pronunciation function. Hutchinson K, Vonhoff F, Duch C (2014) Dscam1 is required for normal dendrite growth and branching but not for dendritic spacing in Drosophila motoneurons. Mol Neurobiol 29:303-320. Die rechteckige Kernburg ist von vier Gebäudeflügeln und einer Schildmauer mit Ecktürmen umgeben. Die spätstaufische Burg der Erzbischöfe und Kurfürsten von Mainz wurde um das Jahr 1245 zum Schutz des Gebiets an der Lahnmündung erbaut. Vonhoff F, Williams A, Ryglewski S, Duch C (2012) Drosophila as a Model for MeCP2 Gain of Function in Neurons. Duch C, Bayline RJ, Levine RB (2000) Development of the DLM flight motor system in Manduca sexta. Advising by appointment only. J Neurophysiol 79:361-370. Burg Lahneck. Mar 19;12:5. doi: 10.3389/fnsys.2018.00005. J Comp Neurol 450:153-166. Biozentrum 1 Hanns-Dieter-Hüsch-Weg 15, 2nd Floor, Room 02.356 D 55128 Mainz Mo. However, in a computing, adapting, and learning system such as the brain, these properties must also retain functional plasticity. (2)Institute of Molecular Biology, Johannes Gutenberg University Mainz, 55099 Mainz, Germany. J Neurophysiol 93:2331-2342. University Information Security and Privacy © 2020 The Arizona Board of Regents on behalf of The University of Arizona.The University of Arizona. Exkursion LL BiMA. Neuroimage 23:1283-1298. J Neurophysiol 100(5):2525-36. Vierk R, Pflueger HJ, Duch C (2010) Postembryonic development of centrally generated flight motor patterns in the hawkmoth, Manduca sexta. Biogenic amines, like norepinephrine, can act as neuromodulators to render animal behavior adaptive to changing external and internal conditions. Kadas D, Ryglewski S, Duch C (2015) Transient BK outward current enhances motoneurone firing rates during Drosophila larval locomotion. 2. To address these questions we use Drosophila melanogaster as a model system. Front Syst Neurosci 11:68, Kadas D, Klein A, Krick N, Worrell JW, Ryglewski S, Duch C (2017) Dendritic and Axonal L-Type Calcium Channels Cooperate to Enhance Motoneuron Firing Output during Drosophila Larval Locomotion. Institute of Neurobiology, Johannes Gutenberg University of Mainz, 55099 Mainz, Germany. Libersat F, Duch C (2002) Morphometric analysis of dendritic remodeling in an identified motoneuron during postembryonic development. J Exp Biol 202:3555-3564. (2018) Structural and Molecular Properties of Insect Type II Motor Axon Terminals. Neurons are the building blocks of the brain. PNAS 111(50):18049-54. In addition to the unprecedented genetic tools available in Drosophila, the transformation from the larval to the adult stage during metamorphosis is a striking example of postembryonic nervous system plasticity and remodeling, and the functions of individually identified neurons can directly be related to stage specific behaviors. Ryglewski S, Duch C (2009) Shaker and Shal mediate transient calcium-independent potassium current in a Drosophila flight motoneuron. J Vis Exp 15;(68). Acta Biol Hung 55:3-12. Neuron 93(3):632-645.e6. We are interested in the functional diversity of voltage gated calcium channels and its implications for normal neurophysiology ans behavior. Methods: Patients meeting selection criteria (IOP one eye 19 mmHg and ≤32 mmHg and IOP both eyes ≤32 mmHg at 8:00 h) were switched to travoprost monotherapy for 4 weeks. Adrenergic signaling profoundly modulates animal behavior. To understand the adaptive regulation of these properties our research objectives are: ⢠identify the molecular mechanisms that regulate electrical and morphological properties of neurons. Arbeitsgruppe/Research team Prof. Dr. C. Duch. J Neurosci 27(41):11122-31. J Comp Neurol, 518:2437-2455. Dev Biol 297(1):214-227. Close affiliations . Institute of Neurobiology, Johannes Gutenberg University of Mainz, Mainz, Germany. Duch C, Vonhoff F, Ryglewski S (2008) Dendrite elongation and dendritic branching are affected separately by different forms of intrinsic motoneuron excitability. 9.00-12.00) Tel. Pflueger HJ, Duch C (2011) Dynamic neural control of insect muscle metabolism related to motor behavior. J Neurosci 20:6950-6961. Morris OT, Duch C, Stevenson PA (1999) Reflex activation of locust octopaminergic modulatory neurons by proprioreceptors responsive to flight muscle contractions. Ryglewski S, Lance K, Levine RB, Duch C (2012) Cav2 Channels Mediate LVA and HVA Calcium Currents in Drosophila Motoneurons. Stefanie Ryglewski, Ph.D., ryglewsk@uni-mainz.de. Approximately 100 billion neurons in our brain form 100 trillion synapses onto 100,000 miles of dendritic cable. Cell Tissue Res 325:175-87. Kadas D, Duch C, Consoulas C. (2019) Postnatal Increases in Axonal Conduction Velocity of an Identified Drosophila Interneuron Require Fast Sodium, L-Type Calcium and Shaker Potassium Channels. doi: 10.1523/ENEURO.0181-19.2019. J Neurophysiol 87:1415-1425. Eur J Neurosci 23:335-349. Front Syst Neurosci. Ryglewski S, Vonhoff F, Scheckel K, Duch C (2017) Intra-neuronal Competition for Synaptic Partners Conserves the Amount of Dendritic Building Material. University Information Security and Privacy © 2020 The Arizona Board of Regents on behalf of The University of Arizona.The University of Arizona. E-mail: sac@unieducar.org.br Fone: 0800.005.3005 Escritório em São Paulo - SP: Av. J Comp Physiol A 184:489-499. OA generally enhances locomotor behaviors such as Drosophila larval crawling and flight, whereas TA decreases locomotor activity. Gaitanidis A, Dimitriadou A, Dowse H, Sanyal S, Duch C, Consoulas C. (2019) Longitudinal assessment of health-span and pre-death morbidity in wild type Drosophila. eNeuro. E-Mail: joerg.korff@uni-mainz… eCollection 2018. Schützler N, Girwert C, Hügli I, Mohana G, Roignant JY, Ryglewski S*, Duch C* (2019) Tyramine action on motoneuron excitability and adaptable tyramine/octopamine ratios adjust Drosophila locomotion to nutritional state. Brain Res Bulletin 53:571-583. DEGREE COURSE: Guide to the Bachelors and Masters Degree Programs Pflueger HJ, Duch C, Heidel E (2004) Neuromodulatory octopaminergic neurons and their functions during insect motor behaviour. Evers JF, Schmitt S, Scholz M, Duch C (2005) New frontiers in functional neuroanatomy: precise automatic reconstruction from confocal image stacks. Eur J Neurosci, 37(6):860-75. J Physiol J Physiol 590(Pt 4):809-25. Additional information about this page. Dev Biol 231:348-363. J Neurophysiol 102:41-58. Physiology, UM Mainz: Amparo Acker-Palmer Cell Biology, GU Frankfurt: Eva-Maria Albers Dept. Aging (Albany NY). Fax +49 6131 39-25548. Duch C, Levine RB (2002) Changes of calcium signaling during postembryonic dendritic growth in Manduca sexta. doi: 10.1523/ENEURO.0181-19.2019. Biozentrum 1 Hanns-Dieter-Hüsch-Weg 15, 2nd Floor, Room 02.352 55128 Mainz Tel: +49 6131/3923419 Fax: +49 6131/3925443 e-mail: cduch@uni-mainz.de. J Comp Physiol 195(5):473-89. Alles zur Johannes-Gutenberg-Universität Mainz und ihren 204 Studiengängen. Mainz é uma cidade independente ( kreisfreie Stadt ) ou distrito urbano ( Stadtkreis ), ou seja, possui estatuto de distrito ( … Vierk R, Pflueger HJ, Duch C (2009) Differential effects of octopamine and tyramine on the central pattern generator for Manduca flight. Kuehn C, Duch C (2008) Expression of two different isoforms of fasciclin II during postembryonic central nervous system remodeling in Manduca sexta. Mol. Brembs B, Christiansen F, Pflueger HJ, Duch C (2007) Flight initiation and maintenance deficits in flies with genetically altered biogenic amine levels. Perturbations cause dendrite shifts and result in defects of adaptive motor control. J Comp Neurol 403:119-134. With approximately 32,000 students (2018) in about 100 schools and clinics, it is among the largest universities in Germany. PLoS Biol 5(4):e66. The promotion and introduction of new ideas, the use of knowledge to improve people’s lives and encourage them to overcome the many boundaries they encounter daily – these are the underlying ambitions of Johannes Gutenberg University Mainz. Ryglewski S, Duch C, Altenhein B (2017) Tyramine Actions on Drosophila Flight Behavior Are Affected by a Glial Dehydrogenase/Reductase. Cell Tissue Res 334:477-498. Duch C, Mentel T (2004) Activity affects dendritic shape and synapse elimination during steroid induced dendritic regression in Manduca sexta. eBook - JaSeAn. Ryglewski S, Duch C (2012) Preparation of Drosophila Central Neurons for in situ Patch Clamping. Börner J, Duch C (2010) A standard neuroanatomy atlas for the adult Drosophila ventral nerve cord. The Ernst Florey memory lecture. However, the mechanisms and cellular targets of TA modulation of locomotor activity are incompletely understood. Ryglewski S, Kilo L, Duch C (2014) Sequential acquisition of cacophony calcium currents, sodium channels and voltage-dependent potassium currents affects spike shape and dendrite growth during postembryonic maturation of an identified Drosophila motoneuron Eur J Neurosci, 39(10):1572-85. Wären Kameras an besonders betroffenen Stellen … Nove de Julho, 5229 - 5° Andar Somos uma instituição de Educação que atua nas áreas de Treinamento em Desenvolvimento Profissional e Gerencial desde fevereiro de 2003. Herrera-Valdez MA, McKiernan EC*, Berger SD*, Ryglewski S, Duch C, Crook S (2013) Relating ion channel expression, bifurcation structure, and diverse firing patterns in a model of an identified motor neuron. mail.uni-mainz.de uses Microsoft HTTPAPI web technologies. Institute of Neurobiology, Johannes Gutenberg University of Mainz, 55099 Mainz, Germany cduch@uni-mainz.de. Duch C, Mentel T (2003) Motoneuron terminal retraction and outgrowth depend on stage-specific activity patterns during the metamorphosis of Manduca sexta. Group leader. Current project. Therefore, even with a complete connectome in hand, understanding brain function requires an intricate analysis of the physiology and functional morphology of its component neurons. Group (private) – Master of Education, Uni Mainz. J Physiol 593(22):4871-88. Accordingly, dendritic defects are consistent anatomical correlates of numerous brain diseases, but specific causality remains unproven. Acta Biol Hung 51:343-348. Int Comp Biol 46:E36. European J Neurosci 17:1-18. J Exp Biol 198:1963-1976. Here we genetically remove dendrites in Drosophila motoneurons, followed by analysis of functional outcomes. 55099 Mainz Germany. Look up the English to German translation of uni Mainz in the PONS online dictionary. PNAS 116(9):3805-3810. Neurobiol of Disease, in press. Uni Mainz. Duch C 2 Affiliations . Email: cduch@uni-mainz.de Search for more papers by this author Vonhoff F, Duch C (2010) Tiling Among Stereotyped Dendritic Branches in an Identified Drosophila Motoneuron. Pflueger HJ, Duch C (2000) The functional role for octopaminergic neurons in insect motor behavior. Vonhoff F, Kühn C, Blumenstock S°, Sanyal S, Duch C (2013) A precise temporal coherency between receptor expression, neural activity, and AP-1 dependent transcription regulates dendrite development in an identified Drosophila motoneuron. J Comp Neurol 422:1-17. Development 140(3):606-16. Kühn C, Duch C (2013) Putative Excitatory and Putative Inhibitory Inputs Localize to Different Dendritic Domains in a Drosophila Flight Motoneuron. eNeuro. J Neurophysiol 102(6):3673-88. 1990-1994 Study of Biology, Free University Berlin 1994 Diploma of Biology, Free University Berlin 1995-1998 PhD Student at the Institute of Neurobiology, Free University Berlin Burkert P, Duch C (2006) Developmental changes of CaMKII localization, activity and function during postembryonic CNS remodeling in Manduca sexta. Duch C, Levine RB (2000) Remodeling of membrane properties and dendritic architecture accompany the postembryonic conversion of a âslowâ into a âfastâ motoneuron. Synapses determine information processing between neurons, whereas electrical properties as well as structure determine information processing within neurons. Raum 01-230 (Gebäude Recht und Wirtschaft I) Tel. We use the versatile genetic model system Drosophila melanogaster for our research. The University of Mainz (full name Johannes Gutenberg University Mainz) (German: Johannes Gutenberg-Universität Mainz) is a public research university in Mainz, Rhineland Palatinate, Germany, named after the printer Johannes Gutenberg since 1946. J Neurosci Methods 15:168(1):64-70. Schmitt S, Evers JF, Scholz M, Duch C, Obermayer K (2004) New methods for the computer assisted 3D reconstruction of neurons from confocal image stacks. and the secretary: Renate Bertgen. Group (open) – Master Erziehungswissenschaft, Uni Mainz. Background: To compare the efficacy and safety of timolol 0.5% versus brinzolamide 1.0% when added to travoprost monotherapy in patients with primary open-angle glaucoma or ocular hypertension. J Comp Physiol A: 195(3):265-77. Prof. Dr. Carsten Duch. Lukas Kilo, Ph.D. Student, kilo@uni-mainz.de Corresponding Author. Stocker B, Bochow C, Damrau C, Mathejczyk T, Wolfenberg H, Colomb J, Weber C, Ramesh N, Duch C, Biserova NM, Sigrist S, Pflüger HJ. Besucheranschrift / Office: Hanns-Dieter-Hüsch-Weg 15 (Gebäude 1578, 2.Stock, 02-352) 55128 Mainz mail.uni-mainz.de links to network IP address 134.93.178.3. Kathryn Scheckel, Carsten Duch Correspondence cduch@uni-mainz.de In Brief Ryglewski et al. Physiology (Bethesda) 26:293-303. Consoulas C, Duch C, Bayline RJ, Levine RB (2000) Behavioral transformations during metamorphosis: remodeling of neural and motor systems. : +49 (0) 6131 / 39 - 21979 Fax: +49 (0) 6131 / 39 - 23 004. J Neurosci 37(45):10971-10982. Group (closed) – BA Erziehungswissenschaften, Uni Mainz. (3)Institute of Developmental Biology and Neurobiology, Johannes Gutenberg University Mainz, 55099 Mainz, Germany; ryglewsk@uni-mainz.de cduch@uni-mainz.de. Meseke M, Evers JF, Duch C (2009) Postembryonic dendritic remodeling of an identified neuron is accompanied by changes in synapse distribution and dendritic input computation. 1. Disease Models & Mechanisms, Dec 3 [Epub ahead of print]. Duch C, Pflueger HJ (1999) DUM neurons in locust flight: a model system for amine mediated peripheral adjustments to a central motor program. Mainz [1] [2] [3] ou Mogúncia [4] [5] (em alemão: Mainz, em latim: Mogontiacum, em francês: Mayence) é uma cidade da Alemanha, capital do estado federal de Renânia-Palatinado. E-Mail. Toplinks. When analyzing the role of dendrites, the experimental challenge is to abolish them selectively in identified Drosophila wing motoneurons without affecting other properties of these specific neurons or others. Mentel T, Duch C, Müller U, Stypa H, Wegener G, Pflueger HJ (2003) Fuel selection in locust flight muscle by the activity of central modulatory neurons. Hohensee S, Bleiss W, Duch C (2008) Correlative electron and confocal microscopy assessment of synapse localization in the central nervous system of an insect. Logo der Johannes Gutenberg-Universität Mainz, Zusätzliche Informationen zu dieser Seite. J Neurosci 24:9826-9837. J Comp Neurol, 518:2169-2185. Libersat F, Duch C (2004) Cellular and molecular mechanisms of the maturation of neuronal dendritic trees. Duch C, Mentel T, Pflueger HJ (1999) Distribution and activation of different types of octopaminergic DUM neurons in the locust. Williams AA, White R, Sniard A, Corneveaux J, Huentelman M, Duch C (2016) MECP2 impairs neuronal structure by regulating KIBRA. Logo der Johannes Gutenberg-Universität Mainz, Zusätzliche Informationen zu dieser Seite. J Comp Physiol A: 196(1):37-50. Proceedings of the National Academy of … Each neuron must acquire a specific âGestaltâ and a defined set of ion channels during development and maintain them within critical ranges throughout life. PLoS One, 7(2):e31835. Consequently, normal brain function relies on the correct regulation of single neuron properties, such as their synaptic connections, morphology, and … report that competitive mechanisms are required to correctly partition synaptic inputs from different transmitter systems on the dendritic arbor of a Drosophila motoneuron. Bayline RJ, Duch C, Levine RB (2001) Nerve-muscle interactions regulate motor terminal growth and myoblast distribution during muscle development. Johannes Gutenberg-Universität Mainz Jakob-Welder-Weg 9 55099 Mainz. awiercze@students.uni-mainz.de, anna.wierczeiko@lir-mainz.de. Meseke M, Evers JF, Duch C (2009) PTX-induced hyperexcitability affects dendritic shape and GABAergic synapse density but not synapse distribution during Manduca postembryonic motoneuron development. Baudoux S, Duch C, Morris OT (1998) Coupling of efferent neuromodulatory neurons to rhythmical leg motor activity in the locust. Börner J , Puschmann T, Duch C (2006) A steroid hormone affects sodium channel expression in Manduca central neurons. Mainz, Renânia-Palatinado, Alemanha: Presidente Georg Krausch Total de estudantes: 37 039 Página oficial website oficial: A Universidade Johannes Gutenberg de Mainz (em alemão: Johannes Gutenberg-Universität Mainz) é uma instituição de ensino superior localizada em Mainz, no estado da Renânia-Palatinado, Alemanha. Ryglewski S, Kadas S, Hutchinson K, Schuetzler N, Vonhoff F, Duch C (2014) Dendrites are dispensable for basic motoneuron function but essential for fine tuning of behavior. The biogenic amines octopamine (OA) and tyramine (TA) modulate insect motor behavior in an antagonistic manner. Mit Erfahrungsberichten, NC-Liste und zulassungsfreien Studiengängen.
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